PHYSICOCHEMICAL PROPERTIES AND STABILITY OF THE NEW HYPOXIA-SELECTIVEAGENT ETHYLAMINO)PROPYL]AMINO]-2-QUINOXALINECARBONITRILE 1,4-DI-N-OXIDE HYDROCHLORIDE

ethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydr ochloride (Q-85 HCl), a new hypoxia-selective agent, was studied to cl arify its physico-chemical properties. Melting point, spectra (UV, IR, NMR, MS), thermal behaviour, solubility, pK(a), partition coefficient and chromatographic characteristics (TLC, HPLC) have been determined. The stability of Q-85 HCl was studied under various conditions by HPL C. Q-85 HCl in solid state was very stable to heat and fairly stable t o light. Some degradation products of Q-85 HCl were identified in basi c solution.