Rapid disappearance of hepatic adenoma after contraceptive withdrawal

We present the case of a 25-year-old woman who developed a large central li ver adenoma after 8 years of continuous oral contraceptive use. The first d iagnosis was made by ultrasonography, after a rise in plasmatic gamma-gluta myl-transpeptidase and alkaline phosphatase levels was noted. Withdrawal of the oral contraceptive was followed by shrinkage of the adenoma, with comp lete disappearance 9 months after the diagnosis. Hepatic adenoma (HA) still presents problems in terms of differential diagnosis and clinical manageme nt. There are reports of complete or partial regression of an HA after disc ontinuation of oral contraceptives, but they are poorly documented. To our knowledge, a patient with such rapid disappearance of a large HA has never been reported.