Clinical and endoscopic features of adult T-cell leukemia/lymphoma with duodenal involvement

We describe three cases of adult T-cell leukemia/lymphoma (ATLL) with duode nal involvement and provide a review of the literature. The first case, a 7 4-year-old woman with acute subtype of ATLL, had multiple polypoid lesions from the bulbus extending into the descending portion of the duodenum. The second case, a 70-year-old man with lymphoma subtype of ATLL, had a polypoi d tumor in the descending portion of the duodenum and multiple protruded le sions in the small and large intestines. The third case, a 67-year-old man with lymphoma subtype, of ATLL, had a flat-elevated lesion in the descendin g portion of the duodenum, as well as a gastric ulcerated lesion. Biopsies from these lesions showed mucosal invasion of ATLL cells in each case. All patients received combination chemotherapy, which was successful in the fir st and third cases, accompanied by the disappearance of gastroduodenal lesi ons.