Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

Authors
Gladysheva, IP Polekhina, OV Karmakova, TA Nemtsova, ER Yakubovskaya, RI Shen, WC Kennedy, AR Larionova, NI
Citation
Ip. Gladysheva et al., Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor, J CONTR REL, 74(1-3), 2001, pp. 303-308
Citations number
9
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF CONTROLLED RELEASE
ISSN journal
01683659 → ACNP
Volume
74
Issue
1-3
Year of publication
2001
Pages
303 - 308
Database
ISI
SICI code
0168-3659(20010706)74:1-3<303:POBCAI>2.0.ZU;2-5
Abstract
The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delive ry of BBI. (C) 2001 Elsevier Science BY. All rights reserved.