BACKGROUND: Focal epithelial hyperplasia (FEH) is an uncommon benign oral c
ondition that occurs mainly in young individuals of certain racial groups.
METHODS: A 21-year-old Caucasian man presented with FEH of the oral mucosa.
The patient was treated with interferon alpha-2a three times a week for 14
weeks intramuscularly (a total of 162 million units).
RESULTS: At 2 months after the end of therapy, the papular lesions showed p
artial regression.
CONCLUSION: This treatment modality should be used in cases with diffuse fo
cal epithelial hyperplasia.