Quantitative structure-activity relationship of some HIV-1 protease inhibitors: A Fujita-Ban type analysis

Authors
Mekapati, SB Sivakumar, R Gupta, SP
Citation
Sb. Mekapati et al., Quantitative structure-activity relationship of some HIV-1 protease inhibitors: A Fujita-Ban type analysis, J ENZ INHIB, 16(3), 2001, pp. 185-197
Citations number
17
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF ENZYME INHIBITION
ISSN journal
87555093 → ACNP
Volume
16
Issue
3
Year of publication
2001
Pages
185 - 197
Database
ISI
SICI code
8755-5093(2001)16:3<185:QSROSH>2.0.ZU;2-6
Abstract
A Fujita-Ban type analysis has been made on a few series of HIV-1 (human im munodeficiency virus of type 1) protease inhibitors and the activity contri butions of various substituents obtained. From these activity contributions , a compound is predicted that may have better activity than ritonavir, pre sently prescribed for the treatment of patients suffering from HIV-1. A few other compounds are also suggested.