Random optimizations for direct heteronuclear correlations

A novel optimization method is described for the acquisition of direct one- bond heteronuclear correlations. The RDSQC (Randomly optimized Direct corre lation Single Quantum Coherence) experiment utilizes an optimization based on the randomly ordered sampling of a range of couplings. The random order of the 1/(2*((1)J(CHmin))) delays removes the signal dependency on a single type of apodization, thus eliminating a significant portion of the F-1 art ifacts induced in the accordion-optimized ADSQC experiment. Compared to the statically optimized GHSQC, the randomly optimized data maintains the desi red signal intensity in most cases, with a small loss for the weakly couple d proton-carbon pairs and significant gains for the more strongly coupled p airs. Compared to the accordion-optimized ADSQC data, the randomly optimize d data afforded similar signal-to-noise without the F-1 modulated artifacts simplifying spectral interpretation.