Preparation of pyrrolo[2,1,5-cd]indolizine derivatives by intramolecular condensation of 3-acyl-5-methylindolizines

An efficient two step route has been developed to synthesize pyrrolo[2,1,5- cd]indolizine derivatives. The reaction sequence proceeds via preparation o f 3-acyl-5-methylindolizines followed by an intramolecular condensation. Th e procedures were carried out under convenient conditions and gave the prod ucts in high yields. It could be expected to be used to prepare a broad ran ge of potentially interesting pyrrolo[2,1,5-cd]indolizine derivatives.