1H-4,5,6,7-tetrahydro-1,3-diazepines. Part II: Basicity and hydrolysis of 1,2-diaryl derivatives

Basicity and alkaline hydrolysis of 1,2-diaryl-1H-4,5,6,7-tetrahydro-1,3-di azepines 1 are studied. Results are analyzed on the basis of Hammett and Sw ain-Lupton constants, finding good structure-basicity correlation when both , inductive and mesomeric effects, are considered together. Regioselectivit y is observed in the alkaline hydrolysis of compounds 1, and it is analyzed in light of the stereoelectronic control theory. Results are compared with those previously obtained for five and six membered ring homologues: 1H-4, 5-dihydroimidazoles and 1,4,5,6-tetrahydropyirimidines respectively.