Thymol derivatives from Eupatorium fortunei

Sixteen new thymol derivatives have been isolated from Eupatorium fortunei and their structures determined based on spectroscopic data. They were clas sified into three groups (i-iii) depending on the oxidation levels: (i) one oxygen function at the 9-position, (ii) two oxygen functions at the 8- and 9-positions, and (iii) three oxygen functions at the 8-, 9-, and 10-positi ons. The hydroxyl groups are acylated with tigloyl, angeloyl, acetyl, isobu tyryl, 3-methyl-2-butenoyl, or 2-methylbutyryl moieties. The compounds havi ng chiral centers showed no specific rotation and exist as racemic mixtures .