New jatrophane diterpenoid esters from Euphorbia turczaninowii

Five new (1-5) and one known (6) jatrophane diterpenoid esters were isolate d from the ethanol extract of the whole herb of Euphorbia. turczaninowii. T heir structures were established by extensive spectroscopic methods. The ab solute stereochemistry of 3 beta ,5 alpha ,8 alpha ,15 beta -tetraacetoxy-7 beta -benzoyloxyjatropha-6(17),11E-dien-9,14-dione (1) was confirmed by a single-crystal X-ray analysis coupled with the exciton chirality circular d ichroism. method. Compounds 1-6 were inactive when evaluated both in a mous e ear inflammation assay and for cytotoxicity against the B16 mouse melanom a cell line.