GnRHa have been used in the treatment of central precocious puberty (CPP) f
or a decade and some final results of this therapy are now available. Treat
ment preserves height potential in younger patients and a complete recovery
of the hypothalamic-pituitary-gonadal axis occurs at the end of treatment.
However, some aspects of the management of CPP are still debated. Probably
the age limits between normal and precocious puberty have to be lowered, a
nd new diagnostic tools will modify and simplify diagnostic criteria. The p
ossibility of progression of premature thelarche into precocious puberty, t
he pathogenesis of organic and idiopathic precocious puberty, the criteria
for decision to treat and to stop treatment and the utility of an associati
on with GH treatment will be better understood in the future. Follow-up of
patients after stopping therapy includes frequency and characteristics of m
enses, the possible higher incidence of polycystic ovary-like syndrome and
the correct achievement of a normal peak bone mass and body composition. In
this review we discuss some of these points, with particular attention to
precocious puberty in girls.