Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacin

A differential-pulse adsorptive stripping voltammetric method for the deter mination of trace amounts of the antibacterial lomefloxacin is proposed, By using an accumulation potential of -0.30 V and a 2 min accumulation time, the linear concentration range of application was 1.0-10.0 ng ml(-1) of lom efloxacin. with a relative standard deviation of 3.8% (for a level of 5.0 n g ml(-1)) and a detection limit of 0.3 ng ml(-1). The method was applied to determination of lomefloxacin in human urine and serum samples. It was val idated using HPLC as a reference method. Recovery levels of the method reac hed 100% in all cases. (C) 2001 Elsevier Science B.V. All rights reserved.