Differences in trace element concentrations between Alzheimer and "normal"human brain tissue using instrumental neutron activation analysis (INAA)

Citation
Ae. Panayi et al., Differences in trace element concentrations between Alzheimer and "normal"human brain tissue using instrumental neutron activation analysis (INAA), J RAD NUCL, 249(2), 2001, pp. 437-441
Citations number
9
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN journal
02365731 → ACNP
Volume
249
Issue
2
Year of publication
2001
Pages
437 - 441
Database
ISI
SICI code
0236-5731(200108)249:2<437:DITECB>2.0.ZU;2-Y
Abstract
Brain samples obtained from the Netherlands Brain Bank were taken from the superior frontal gyrus, superior parietal gyrus and medial temporal gyrus o f 'normal' and Alzheimer's disease subjects in order to determine elemental concentrations and compare elemental composition. Brain samples from the c ortex were taken from 18 subject, eight 'normals' (6 males and 2 females) a nd eleven with Alzheimer's disease, (1 male and 10 females) and the followi ng elemental concentrations, Na, K, Fe, Zn, Se, Br, Rb, Ag, Cs, Ba, and Eu were determined by instrumental neutron activation analysis (INAA). The ele ment which showed the greatest difference was Br, which was found to be sig nificantly elevated in the cortex of Alzheimer's disease brains as compared to the 'normals' at significance (p <0.001).