Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus

We describe a patient who underwent successful BMT from her sibling for the treatment of adult T-cell leukemia/lymphoma. Pre-transplant examination of the donor revealed oligoclonal integration of HTLV-1 proviruses within the germ line, and our concern was that clinical sequelae of HLTV-1 infection might become evident in the setting of post-transplant immunosuppression. H owever, the patient has been in complete remission for 14 months after tran splantation, and no clonality of HTLV-1 provirus was detected in the periph eral blood cells using southern blotting analysis. Our experience supports the possibility of transplantation from HTLV-1 positive donors.