One-pot quinazolin-4-ylidenethiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate

Authors
Fathalla, WM Cajan, M Marek, J Pazdera, P
Citation
Wm. Fathalla et al., One-pot quinazolin-4-ylidenethiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate, MOLECULES, 6(7), 2001, pp. 574-587
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MOLECULES
ISSN journal
14203049 → ACNP
Volume
6
Issue
7
Year of publication
2001
Pages
574 - 587
Database
ISI
SICI code
1420-3049(200107)6:7<574:OQSVN>2.0.ZU;2-3
Abstract
1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were sy nthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyana te (3) with secondary amines. The products underwent transamination reactio ns. Compounds 8a-8g were identified by FTIR, H-1-NMR, C-13-NMR, mass spectr oscopy and X-ray crystallography.