One-pot quinazolin-4-yl-thiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate

Authors
Fathalla, W Cajan, M Marek, J Pazdera, P
Citation
W. Fathalla et al., One-pot quinazolin-4-yl-thiourea synthesis via N-(2-cyanophenyl)benzimidoyl isothiocyanate, MOLECULES, 6(7), 2001, pp. 588-602
Citations number
10
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MOLECULES
ISSN journal
14203049 → ACNP
Volume
6
Issue
7
Year of publication
2001
Pages
588 - 602
Database
ISI
SICI code
1420-3049(200107)6:7<588:OQSVN>2.0.ZU;2-R
Abstract
1-substituted-3-(2-phenylquinazolin-4-yl) thioureas (7) were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenylimi no)phenylmethyl] thioureas (3). These compounds in turn were prepared by th e reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate (2) with primary amines. The structures of products 7 were confirmed by FTIR, H-1-NMR, C-13- NMR, mass spectroscopy and X-ray crystallography.