Effect of food on the bioavailability of 100-mg Dilantin Kapseals

The authors examined the effect of food on the bioavailability of Dilantin Kapseals in a nonblinded, single 100-mg dose, randomized, crossover trial. Drug was administered after an 8-hour fast and after a high-fat meal. Diffe rences in mean dietary state values were +6% for maximum concentrations (C- max) and -2% for area under the curve. Associated 90% CI were within US Foo d and Drug Administration criteria, confirming the absence of a food effect . Thus, patients may take 100-mg Dilantin Kapseals without regard to meals.