Mathematical modelling of the ischaemic heart

Recent advances in high performance computing combined with increasing know ledge of them kinetics of biochemical reactions and transport processes hav e allowed us to develop mathematical models that describe various aspects o f cardiac physiology. These models include both single cell and three-dimen sional tissue models that simulate important features of cardiac electrophy siology, mechanics, and metabolism. We have begun to couple these models wi th the goal of creating a fully integrated cardiac model that can describe the pathophysiology of the ischaemic heart. Here we present an outline of t his work.