Biological evaluation of 2-fluoro-2-[I-123]iodo-mannose (FIM): biological evaluation of FIM

This paper describes the biodistribution of a radio-iodinated analog of flu orodeoxyglucose (FDG), I-123-2-fluoro-2-iodo-mannose (FIM) was investigated as a potential single photon emission tomography (SPECT) imaging agent. We also compare the results with the observed distribution of the classical P ET agent F-18-FDG and newly developed F-18-difluorodeoxyglucose (DFDG). Fol lowing radioiodination, the final product was stable in-vitro for 24 hrs. M ice showed a rapid blood clearance and deiodination of the I-123-FIM reflec ted by high stomach and thyroid uptake. Comparison with F-18-FDG and F-18-D FDG revealed a large discrepancy between the F-18 labeled sugars and the I- 123-FIM biological distribution. The iodinated product was not found to be a metabolic marker for in-vivo studies. (C) 2001 Elsevier Science Inc. All rights reserved.