Synthesis and properties of F-18-labeled potential myocardial blood flow tracers

Authors
Studenov, AR Berridge, MS
Citation
Ar. Studenov et Ms. Berridge, Synthesis and properties of F-18-labeled potential myocardial blood flow tracers, NUCL MED BI, 28(6), 2001, pp. 683-693
Citations number
30
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
28
Issue
6
Year of publication
2001
Pages
683 - 693
Database
ISI
SICI code
0969-8051(200108)28:6<683:SAPOFP>2.0.ZU;2-8
Abstract
PET centers without particle accelerators make clinical PET widely availabl e at reduced cost. For myocardial perfusion tracers, these satellite PET ce nters are limited to generator- produced Rb-82(+) and Cu-62[PTSM]. Their li mitations motivate a search for transportable alternatives. In search of ne w tracers we have synthesized several F-18-labeled amines and quaternary am monium salts. Among them, 4-[F-18]fluorotri-N-methylanilinium ([F-18]FTMA) has flow-tracing proper-ties. The compound is functional, but has propertie s that justify a continued search. (C) 2001 Elsevier Science Inc. All right s reserved.