Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines

Authors
Aggarwal, VK de Vicente, J Bonnert, RV
Citation
Vk. Aggarwal et al., Catalytic cyclopropanation of alkenes using diazo compounds generated in situ. A novel route to 2-arylcyclopropylamines, ORG LETT, 3(17), 2001, pp. 2785-2788
Citations number
28
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
17
Year of publication
2001
Pages
2785 - 2788
Database
ISI
SICI code
1523-7060(20010823)3:17<2785:CCOAUD>2.0.ZU;2-W
Abstract
[GRAPHICS] A user-friendly, one-pot process for catalytic cyclopropanation of alkenes from tosylhydrazones is described. The cyclopropanation of N-vinylphthalimi de provides a new route to 2-arylcyclopropylamines, and this is exemplified in the efficient synthesis of the HIV-1 reverse transcriptase inhibitor 6.