Estrogenic activity of phenolic compounds from Nigella damascena evaluatedusing a recombinant yeast screen

Authors
Agradi, E Fico, G Cillo, F Francisci, C Tome, F
Citation
E. Agradi et al., Estrogenic activity of phenolic compounds from Nigella damascena evaluatedusing a recombinant yeast screen, PLANTA MED, 67(6), 2001, pp. 553-555
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
6
Year of publication
2001
Pages
553 - 555
Database
ISI
SICI code
0032-0943(200108)67:6<553:EAOPCF>2.0.ZU;2-8
Abstract
We used a yeast estrogen screen (YES) containing human estrogen receptor to evaluate the estrogenic activity of both crude extracts and simple pure ph enolic compounds from Nigella damascena seeds. Estrogenic activity was esta blished in the methanolic and aqueous extracts of the seeds as well as in t wo simple phenolic compounds isolated from the methanolic extract, 2,4-dihy droxyphenylacetic acid, 3,4-dihydroxy-beta -phenethyl alcohol.