A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale

Authors
Lee, JR Yang, MS Jang, DS Ha, TJ Park, KM Lee, CH Kho, YH Park, KH
Citation
Jr. Lee et al., A new guaianolide as apoptosis inhibitor from Chrysanthemum boreale, PLANTA MED, 67(6), 2001, pp. 585-587
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
67
Issue
6
Year of publication
2001
Pages
585 - 587
Database
ISI
SICI code
0032-0943(200108)67:6<585:ANGAAI>2.0.ZU;2-8
Abstract
The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named bore nolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC50 value of 6.2 mug/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crys tallographic analysis.