MAXIKDIOL - A NOVEL DIHYDROXYISOPRIMANE AS AN AGONIST OF MAXI-K CHANNELS

Authors
SINGH SB GOETZ MA ZINK DL DOMBROWSKI AW POLISHOOK JD GARCIA ML SCHMALHOFER W MCMANUS OB KACZOROWSKI GJ
Citation
Sb. Singh et al., MAXIKDIOL - A NOVEL DIHYDROXYISOPRIMANE AS AN AGONIST OF MAXI-K CHANNELS, Journal of the Chemical Society. Perkin transactions. I, (22), 1994, pp. 3349-3352
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
22
Year of publication
1994
Pages
3349 - 3352
Database
ISI
SICI code
0300-922X(1994):22<3349:M-ANDA>2.0.ZU;2-E
Abstract
Maxi-K (large-conductance calcium-activated potassium) channels are a family of proteins which are thought to play an important role in cont rolling the contractility of airway smooth muscle. Maxikdiol is a nove l, 1,5-dihydroxyisoprimane, diterpenoid which acts as an agonist of th e channel. The isolation, structure elucidation and biological activit y of maxikdiol are described.