Accelerated atheroma, antiphospholipid antibodies, and the antiphospholipid syndrome

Authors
George, J Haratz, D Shoenfeld, Y
Citation
J. George et al., Accelerated atheroma, antiphospholipid antibodies, and the antiphospholipid syndrome, RHEUM DIS C, 27(3), 2001, pp. 603
Citations number
72
Categorie Soggetti
Rheumatology
Journal title
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
ISSN journal
0889857X → ACNP
Volume
27
Issue
3
Year of publication
2001
Database
ISI
SICI code
0889-857X(200108)27:3<603:AAAAAT>2.0.ZU;2-P
Abstract
Indirect data coming from animal studies and in vitro observations support the contention that the mere presence of antiphospholipid antibodies may be sufficient to increase atheroma. development, regardless of other predispo sing factors. It seems that humoral and cellular immune responses to beta ( 2)-glycoprotein I can play an important role in mediating the increased pro pensity to atherosclerosis.