Asymmetric reduction of ketones with sodium aluminum hydride modified withchiral amino alcohols

Authors
Vinogradov, MG Mikhalev, OV Pavlov, VA Ferapontov, VA Malyshev, OR Heise, GL
Citation
Mg. Vinogradov et al., Asymmetric reduction of ketones with sodium aluminum hydride modified withchiral amino alcohols, RUSS CHEM B, 50(5), 2001, pp. 843-845
Citations number
7
Categorie Soggetti
Chemistry
Journal title
RUSSIAN CHEMICAL BULLETIN
ISSN journal
10665285 → ACNP
Volume
50
Issue
5
Year of publication
2001
Pages
843 - 845
Database
ISI
SICI code
1066-5285(200105)50:5<843:AROKWS>2.0.ZU;2-A
Abstract
Asymmetric reduction of ketones with hydride complexes, which were prepared by in situ modification of NaAlH4, with various chiral amino alcohols or d iamines, was studied. The highest enantioselectivity (up to 93% ee) was ach ieved using 2-(hydroxydiphenyl-methyl)pyrrolidine as a chiral inducing agen t.