Oxidatively sonochemical dealkylation of various N-alkylsulfonamides to free sulfonamides and aldehydes

Various N-alkylsulfonamides were easily dealkylated to give the correspondi ng free sulfonamides in moderate to good yields in the presence of (diaceto xyiodo)benzene and iodine under ultrasonic irradiation. Application of this methodology to various AT-protected alkylamines with sulfonyl, phosphonyl, and acyl groups was carried out, and the oxidative conversion occurred onl y in N-sulfonyl-protected phenylalkylamines to give the corresponding aldeh ydes together with free sulfonamides in moderate to good yields. (C) 2001 E lsevier Science Ltd. All rights reserved.