P(RNCH2CH2)(3)N-catalyzed diastereoselective synthesis of oxazolines

Authors
Kisanga, P Ilankumaran, P Verkade, JG
Citation
P. Kisanga et al., P(RNCH2CH2)(3)N-catalyzed diastereoselective synthesis of oxazolines, TETRAHEDR L, 42(36), 2001, pp. 6263-6266
Citations number
34
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
36
Year of publication
2001
Pages
6263 - 6266
Database
ISI
SICI code
0040-4039(20010903)42:36<6263:PDSOO>2.0.ZU;2-B
Abstract
We report herein that the strong nonionic bases P(RNCH2CH2)(3)N(R=Mc, 1a; i -Pr, 1b) catalyze the diastereoselective synthesis of thirteen oxazolines i n the presence of 5-30% of these catalysts. The formation of the oxazolines proceeds under very mild conditions in good to excellent yields with high dia stereo selectivity (> 95.5) for the trans isomer. (C) 2001 Elsevier Sci ence Ltd. All rights reserved.