Synthesis of the racemic tetracyclic core of CP-225,917 - a model compoundlacking the sidearms of the natural product

Authors
Clive, DLJ Sun, SY
Citation
Dlj. Clive et Sy. Sun, Synthesis of the racemic tetracyclic core of CP-225,917 - a model compoundlacking the sidearms of the natural product, TETRAHEDR L, 42(36), 2001, pp. 6267-6270
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
36
Year of publication
2001
Pages
6267 - 6270
Database
ISI
SICI code
0040-4039(20010903)42:36<6267:SOTRTC>2.0.ZU;2-3
Abstract
Compound 3, representing the tetracyclic core structure of CP-225,917, was prepared from bridgehead olefin 9, which was first converted into ketone 13 . Peterson olefination then gave 15, and this was elaborated into the anhyd ride 19, from which crystalline 3 was reached by a sequence of deprotection and oxidation steps. (C) 2001 Elsevier Science Ltd. All rights reserved.