Stereoselective intramolecular radical addition of polyhaloacyl pendant groups to the 1,3-dihydro-2-imidazolone moiety: the chiral synthesis of threo-diaminocarboxylic acids
T. Katahira et al., Stereoselective intramolecular radical addition of polyhaloacyl pendant groups to the 1,3-dihydro-2-imidazolone moiety: the chiral synthesis of threo-diaminocarboxylic acids, TETRAHEDR L, 42(36), 2001, pp. 6319-6322
The intramolecular Ru(II)-catalyzed radical addition of trichloroacetyl and
2,2-dichloro-4-hexenoyl pendant groups to a 1,3-dihydro-2-imidazolone moie
ty provides a perfectly stereocontrolled approach to the preparation of 1,2
-diamines which contain contiguous multi-stereocenters. Typical examples fo
r this approach are given by the chiral synthesis of vicinal-diaminocarboxy
lic acids, which are amino analogs of statine and MeBmt. (C) 2001 Elsevier
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