Dihalomethylation of N-protected phenylalanine esters

Authors
Onishi, T Otake, Y Hirose, N Nakano, T Torii, T Nakazawa, M Izawa, K
Citation
T. Onishi et al., Dihalomethylation of N-protected phenylalanine esters, TETRAHEDR L, 42(36), 2001, pp. 6337-6340
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
36
Year of publication
2001
Pages
6337 - 6340
Database
ISI
SICI code
0040-4039(20010903)42:36<6337:DONPE>2.0.ZU;2-V
Abstract
Dihalomethylation of several N-protected amino acid esters gave N-protected alpha -aminoalkyl-alpha ' -dihalomethylketones, which are useful intermedi ates for the synthesis of erythro P-amino-a-hydroxycarboxylic acids, in goo d yield. The dihalomethylketones were successfully converted to N-protected alpha -aminoalkyl-alpha ' -halomethylketones by selective catalytic hydrog enation. (C) 2001 Elsevier Science Ltd. All rights reserved.