Synthesis of benzo[b]thiophenes by electrophilic cyclization

Authors
Larock, RC Yue, DW
Citation
Rc. Larock et Dw. Yue, Synthesis of benzo[b]thiophenes by electrophilic cyclization, TETRAHEDR L, 42(35), 2001, pp. 6011-6013
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
35
Year of publication
2001
Pages
6011 - 6013
Database
ISI
SICI code
0040-4039(20010827)42:35<6011:SOBBEC>2.0.ZU;2-P
Abstract
2,3-Disubstituted benzo[b]thiophenes are readily prepared in excellent yiel ds under very mild reaction conditions by the Pd Cu-catalyzed cross-couplin g of commercially available o-iodothioanisole a-nd terminal alkynes, follow ed by electrophilic cyclization Gy I-2, Br-2, NBS, p-O2NC6H4SCl or PhSeCl. (C) 2001 Published by ElseNier Science Ltd.