Synthesis of enantiomerically pure 3-aminochroman derivatives

Enantiomerically pure (3R)-amino-5-methoxy-3,4-dihydro-2H-1-benzopyran was successfully synthesised in nine steps starting from L-serine. The same syn thetic pathway was used to prepare the (3 S) -aminochroman derivative start ing from D-serine. The enantiomeric purity of the final aminochroman deriva tives was determined by capillary electrophoresis using P-cyclodextrin as t he chiral selector. (C) 2001 Elsevier Science Ltd. All rights reserved.