Efficient enantioselective synthesis of (2R,3R)- and (2S,3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution

Authors
Makino, K Okamoto, N Hara, O Hamada, Y
Citation
K. Makino et al., Efficient enantioselective synthesis of (2R,3R)- and (2S,3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution, TETRAHEDR-A, 12(12), 2001, pp. 1757-1762
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
12
Issue
12
Year of publication
2001
Pages
1757 - 1762
Database
ISI
SICI code
0957-4166(20010716)12:12<1757:EESO(A>2.0.ZU;2-W
Abstract
(2R,3R)- and (2S,3S)-3-Hydroxyleucines, components of cyclodepsipeptides, p apuamides and polyoxypeptins, were efficiently synthesized along with their diastereomers from the corresponding beta -keto-alpha -amino acid ester th rough dynamic kinetic Z ' resolution using RuCl2(binap)-catalyzed hydrogena tion. (C) 2001 Elsevier Science Ltd. All rights reserved.