G. Zanoni et al., Enantioselective synthesis of cis-1,2-dialkyl substituted cyclopentanoid and isoprostane building blocks via 6-exo-trigonal radical cyclizations, TETRAHEDR-A, 12(12), 2001, pp. 1785-1792
Two different 6-exo-trigonal cyclizations of enantiomerically enriched 6-he
ptenyl radicals readily afforded versatile synthetic precursors of cis-1,2-
dialkyl substituted cyclopentane derivatives. Starting from one of these in
termediates, we accomplished an enantiospecific formal synthesis of two imp
ortant isoprostanes, namely 15-F-2c-IsoP and ent-15-F-2c-IsoP. (C) 2001 Els
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