Hospitalisation for upper gastrointestinal bleeding associated with use oforal anticoagulants

The incidence of hospitalisation for upper GI bleeding with use of oral ant icoagulants (OA) alone or in combination with other drugs was examined in a cohort of 4,204 users of OA, identified through record linkage between a p opulation-based prescription database and a hospital discharge registry in Denmark, and compared with the incidence in the general population not expo sed to OA. The standardised incidence ratio (SIR) was 2.8 (95 % Cl = 1.6-4. 5) for use of OA alone. SIRs tended to be higher for use of OA combined wit h acetaminophen alone (4.4, 95% CI = 1.2-11.4), non-aspirin NSAIDs alone (8 .0, 95% Cl = 2.1 to 20.4) or aspirin/corticosteroids alone (3.8, 95% CI = 0 .8-11.0), respectively. These results indicate that use of OA is associated with a significantly in creased risk of upper GI bleeding, with still higher risks associated with the concomitant use of other medications including acetaminophen. Further r esearch is needed to clarify the extent to which drugs interacting with ora l anticoagulants may cause GI bleeding and the mechanisms through which the se associations operate.