FURTHER-STUDIES ON THE RECOUPLING EFFECT OF 6-KETOCHOLESTANOL UPON OXIDATIVE-PHOSPHORYLATION IN UNCOUPLED LIVER-MITOCHONDRIA

Authors
CUELLAR A RAMIREZ J INFANTE VM CHAVEZ E
Citation
A. Cuellar et al., FURTHER-STUDIES ON THE RECOUPLING EFFECT OF 6-KETOCHOLESTANOL UPON OXIDATIVE-PHOSPHORYLATION IN UNCOUPLED LIVER-MITOCHONDRIA, FEBS letters, 411(2-3), 1997, pp. 365-368
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
411
Issue
2-3
Year of publication
1997
Pages
365 - 368
Database
ISI
SICI code
0014-5793(1997)411:2-3<365:FOTREO>2.0.ZU;2-L
Abstract
The effect of 6-ketocholestanol was studied on CCCP-induced uncoupling in liver mitochondria, submitochondrial particles and cytochrome oxid ase proteoliposomes. It was found that 6-ketocholestanol prevents and reverses uncoupling induced by nM concentrations of CCCP on the three systems assayed. As it was reported on kidney mitochondrial membranes [Chavez et al. (1996) FEES Lett. 379, 305-308], the recoupling effect caused by 6-ketocholestanol on submitochondrial particles and proteoli posomes could be due to a diminution of membrane fluidity. (C) 1997 Fe deration of European Biochemical Societies.