Single nucleotide polymorphisms and recombination rate in humans

Authors
Nachman, MW
Citation
Mw. Nachman, Single nucleotide polymorphisms and recombination rate in humans, TRENDS GEN, 17(9), 2001, pp. 481-485
Citations number
43
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
17
Issue
9
Year of publication
2001
Pages
481 - 485
Database
ISI
SICI code
0168-9525(200109)17:9<481:SNPARR>2.0.ZU;2-J
Abstract
Levels of heterozygosity for single nucleotide polymorphisms vary by more t han one order of magnitude in different regions of the human genome. Region al differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level.