PPAR gamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease

Authors
Wada, K Nakajima, A Blumberg, RS
Citation
K. Wada et al., PPAR gamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease, TRENDS MO M, 7(8), 2001, pp. 329-331
Citations number
27
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
TRENDS IN MOLECULAR MEDICINE
ISSN journal
14714914 → ACNP
Volume
7
Issue
8
Year of publication
2001
Pages
329 - 331
Database
ISI
SICI code
1471-4914(200108)7:8<329:PGAIBD>2.0.ZU;2-I
Abstract
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that is known to play a central role in adipocyte differentiation and insulin sensitivity. Through work in several animal models of intestina l inflammation, it is now recognized that PPAR gamma also inhibits tissue i njury associated with immune activation. These studies point to PPAR gamma as a novel anti-inflammatory mediator with broad therapeutic potential.