Today, 42% of Americans use alternative nonprescription therapies to treat
medical conditions; 46% of nonprescription alternative use for principal me
dical conditions is done without consulting either a medical doctor or a no
nphysician practitioner of alternative therapy. Many nontraditional alterna
tives are used to treat the hot flashes and somatic complaints of menopause
, for which options such as hormone replacement therapy and other prescript
ion and over-the-counter drugs are also available. To date, no one agent tr
eats all menopausal symptoms as effectively as estrogen. Selective estrogen
-receptor modulators can help prevent osteoporosis but do not relieve menop
ausal symptoms. However, some women are unwilling or unable to take hormone
replacement therapy, and some decide to discontinue therapy. Evidence supp
orting the use of some nonprescription alternatives for conditions related
to menopause is limited. Patients need to be aware of the potential for dru
g interactions when these alternative therapies are used concomitantly with
prescription drugs. The current evidence to support use of hormone replace
ment therapy, selective estrogen-receptor modulators, and nontraditional al
ternatives is reviewed here.