A. Nakamura et al., LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice, AM J P-HEAR, 281(3), 2001, pp. H1104-H1112
Citations number
25
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Transverse aortic constriction (TAC) is an effective technique for inducing
left ventricular (LV) hypertrophy in mice. With the use of transthoracic e
chocardiography and Doppler measurements, we studied the effects of an acut
e increase in pressure overload on LV contractile performance and peak syst
olic wall stress index (WSI) at early time points after TAC and the time co
urse of the development of LV hypertrophy in mice. The LV mass index was si
milar between TAC and sham-operated mice at postoperative day 1 but progres
sively increased in TAC mice by day 10. There was no further increase in th
e LV mass index between postoperative days 10 and 20. On day 1, whereas pea
k systolic WSI increased significantly, the LV ejection fraction (LVEF) and
percent fractional shortening (%FS) decreased in TAC mice compared with sh
am-operated mice. By day 10, peak systolic WSI, LVEF, and %FS had recovered
to baseline levels and were not significantly different between postoperat
ive days 10 and 20. Thus LV systolic performance in mice declines immediate
ly after TAC, associated with increased peak systolic WSI, but recovers to
baseline levels with the development of compensatory LV hypertrophy over 10
-20 days.