Citation
Ym. Huang et Zj. Zhang, Flow injection chemiluminescent analysis of isoniazid by direct hexacyanoferrate(III) oxidation, ANAL LETTER, 34(10), 2001, pp. 1703-1710
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL LETTERS
ISSN journal
00032719
→ ACNP
Volume
34
Issue
10
Year of publication
2001
Pages
1703 - 1710
Database
ISI
SICI code
0003-2719(2001)34:10<1703:FICAOI>2.0.ZU;2-U
Abstract
A very simple chemiluminescence (CL) flow system is described for the deter
mination of isoniazid based on its direct oxidation by hexacyanoferrate(III
) solution in an alkaline media. The system responds linearly to isoniazid
concentration in the range 0.05-2 mug/mL with a detection limit (3 sigma) o
f 0.01 mug/mL. Relative standard deviation (RSD) is 1.6% for 0.5 mug/mL of
isoniazid (n=11). The system has been successfully applied to the determina
tion of isoniazid in pharmaceutical preparations. The measurement could be
performed in 30 s with sampling rate of 120 times per hour.