Malignant hyperthermia and multiple organ failure.

The typical explosive form of malignant hyperthermia caused by following is oflurane anaesthesia is a well-known phenomenon. Nevertheless, since dantro lene is used, its evolution toward a multiple organ failure has been rarely described. We report a case of typical explosive malignant hyperthermia ca used by an isoflurane anaesthesia complicated by a cardiovascular failure, a disseminated intravascular coagulation, an acute liver failure and an acu te renal failure. Afterwards, muscle weakness of the right calf was the onl y aftermath. (C) 2001 Editions scientifiques et medicales Elsevier SAS.