New DNA sequencing methods

The Human Genome Project and other major genomic sequencing projects have p ushed the development of sequencing technology. In the past six years alone , instrument throughput has increased 15-fold. New technologies are now on the horizon that could yield massive increases in our capacity for de novo DNA sequencing. This review presents a summary of state-of-the-art technolo gies for genomic sequencing and describes technologies that may be candidat es for the next generation of DNA sequencing instruments.