Fg. De Waart et al., Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers, ATHEROSCLER, 158(1), 2001, pp. 227-231
Citations number
21
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
We hypothesize that smokers with the null genotype for GSTM1 (GSTM1-0), who
thus lack the detoxification enzyme glutathione S-transferase mu1, develop
atherosclerosis at an increased rate compared to smokers with the positive
genotype (GSTM1-1). We used data from a 2-year randomized placebo-controll
ed trial on the effect of vitamin E on atherosclerosis among 189 male smoke
rs. Progression of atherosclerosis was measured by 2-year change of the com
mon carotid intima media thickness (CCA-IMT) as measured by B-mode ultrason
ography. The frequency of GSTM1-0 genotype was 0.5 in both the placebo and
the vitamin E group. Smokers with GSTM1-0 genotype had a tendency to higher
baseline CCA-IMT values than those with GSTM1-1 (0.97 versus 0.92 mm, P =
0.09). Within the placebo group, more CCA-IMT progression was found for smo
kers with the GSTM1-0 than for smokers with the GSTM1-1 genotype after adju
stment for baseline IMT and major CVD risk factors (0.050 versus -0.002 mm,
P = 0.046). In the vitamin E group no effect of GSTM1 genotype on atherosc
lerosis progression was found. Overall, smokers with GSTM1-0 genotype had a
higher mean 2-year progression compared to those with GSTM1-1 as shown by
a difference in increase of 0.042 mm (95% CI 0.006; 0.078, P = 0.02). In co
nclusion, our data suggest that smokers lacking the detoxifying enzyme GST
mu1 develop progression of atherosclerosis at an increased rate. (C) 2001 E
lsevier Science Ireland Ltd. All rights reserved.