Background: The airline pilot works within a complex exposure environment t
hat may present physiological challenges to long-term health. Methods: This
study investigated self-reported disease outcomes among a large group of a
ctive and retired commercial airline pilots in the United States and Canada
. A survey methodology was used, including the collection of historical inf
ormation. Results: Of 10,678 surveys mailed, 6609 were returned (6533 men,
63 women). Given the limitations of survey methodology, increased disease r
ates among pilots were suggested for melanoma, motor neuron disease, and ca
taracts. However, rates for other diseases were in general lower than those
for the U.S. population. Conclusions: Further study has been initiated to
verify and follow reported cases, to expand the study to a larger group, an
d to collect more in-depth information on flight histories, occupational ex
posures, and lifestyle factors.