Hepatocyte-specific porous polymer-scaffolds of alginate/galactosylated chitosan sponge for liver-tissue engineering

Authors
Yang, J Chung, TW Nagaoka, M Goto, M Cho, CS Akaike, T
Citation
J. Yang et al., Hepatocyte-specific porous polymer-scaffolds of alginate/galactosylated chitosan sponge for liver-tissue engineering, BIOTECH LET, 23(17), 2001, pp. 1385-1389
Citations number
10
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
23
Issue
17
Year of publication
2001
Pages
1385 - 1389
Database
ISI
SICI code
0141-5492(200109)23:17<1385:HPPOAC>2.0.ZU;2-5
Abstract
Porous scaffolds of alginate/galactosylated chitosan (ALG/GC) sponges were prepared by lyophilization for liver-tissue engineering. Primary hepatocyte s in ALG/GC sponges showed higher cell attachment and viability than in alg inate alone owing to the specific interaction of the asialoglycoprotein rec eptors on hepatocyte with the galactose residues on ALG/GC sponges. Improve ments in spheroid formation and long-term liver-specific functions of the i mmobilized hepatocyte were also observed in ALG/GC sponge.