Influence of anesthesia on brain distribution of [C-11]methamphetamine in monkeys in positron emission tomography (PET) study

Authors
Mizugaki, M Nakagawa, N Nakamura, H Hishinuma, T Tomioka, Y Ishiwata, S Ido, T Iwata, R Funaki, Y Itoh, M Higuchi, M Okamura, N Fujiwara, T Sato, M Shindo, K Yoshida, S
Citation
M. Mizugaki et al., Influence of anesthesia on brain distribution of [C-11]methamphetamine in monkeys in positron emission tomography (PET) study, BRAIN RES, 911(2), 2001, pp. 173-175
Citations number
9
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
911
Issue
2
Year of publication
2001
Pages
173 - 175
Database
ISI
SICI code
0006-8993(20010824)911:2<173:IOAOBD>2.0.ZU;2-H
Abstract
We investigated the influence of anesthesia on the brain distribution of [C -11]methamphetamine (MAP) obtained by the positron emission tomography (PET ) using the normal rhesus monkeys. We clarified that the brain uptake of [C -11]MAP under halothane anesthesia was faster and higher than that under pe ntobarbital. The difference of the effect of anesthesia is an important pro blem in pharmacokinetic study in PET with experimental animals. (C) 2001 El sevier Science B.V. All rights reserved.