J. Wehner et K. Neuber, Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema, BR J DERM, 145(2), 2001, pp. 302-305
Background Chronic skin colonization with Staphylococcus aureus is a charac
teristic feature of atopic eczema (AE), and about 60% of S. aureus strains
isolated from the skin of patients with AE secrete enterotoxins. Furthermor
e. IgE antibodies to S. aureus enterotoxins have been identified in 78% of
patients with AE.
Objectives To examine the S. aureus enterotoxin-induced histamine and leuko
triene release of basophils from patients with AE.
Methods Peripheral blood basophils from patients with AE were stimulated wi
th the staphylococcal enterotoxins A. B. D. E and toxic shock syndrome toxi
n-1. Additionally, priming experiments were performed with interleukin (IL)
-3, IL-8 and granulocyte/macrophage colony-stimulating factor followed by s
timulation with S. aureus enterotoxins.
Results In patients with AE. basophils secreted significantly higher amount
s of histamine and leukotriene C-4 (LTC4) than in healthy controls. The pri
ming experiments showed additional histamine and LTC4 release in the group
of AE patients.
Conclusions Histamine and leukotriene generation from atopic basophils stim
ulated with staphylococcal enterotoxins may indicate a role for these toxin
s as possible allergens in at least a subgroup of patients with AE.